publications

selected publications

Crossley M, Benjamin PR, Kemenes G, Staras K#*, Kemenes I* (2023) A circuit mechanism linking past and future learning through shifts in perception. Science Advances. DOI: 10.1126/sciadv.add3403. #Corresponding *Joint senior

Biasetti L, Rey S, Fowler M, ..., Varga-Caballero M, Serpell L, Staras K. (2022) Elevated amyloid beta disrupts the nanoscale organization and function of synaptic vesicle pools in hippocampal neurons. Cereb Cortex (in press).

Janiak FK, Bartel P, Bale M, Yoshimatsu T, Komulainen EH, Zhou M, Staras K, Prieto Godino LL, Euler T, Maravall M, Baden T. (2022) Non-Telecentric Two-photon Microscopy for 3D Random Access Mesoscale Imaging. Nature Comms. 13:544.

Komulainen E, Badman J, Rey S, Rulten S, Ju L, Fennell K, Kalasova I, Ilievova K, McKinnon PJ, Hanzlikova H, Staras K*, Caldecott KW*. (2021) Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures. EMBO Rep. 22:e51851.

Rey S, Marra V, Smith C, Staras K. (2020) Nanoscale Remodeling of Functional Synaptic Vesicle Pools in Hebbian Plasticity. Cell Rep. 30:2006-2017.

Crossley M, Staras K*, Kemenes G*. (2018) A central control circuit for encoding perceived food value. Science Advances. 21 doi: 10.1126/sciadv.aau9180. *joint senior and corresponding.

Roshchin M, Matlashov ME,..., Kemenes G*, Staras, K*, Nikitin, ES* (2018) A BK-channel-mediated feedback pathway links single-synapse activity with action potential sharpening in repetitive firing. Science Advances. 4(7):eaat1357 *joint senior and corresponding.

Hoch NC, Hanzlikova H, Rulten SL, Tétreault M, Komulainen E, Ju L, Hornyak P, Zeng Z, Gittens W, Rey SA, Staras K, … Caldecott KW (2017) XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia. Nature. doi: 10.1038/nature20790.

Crossley M, Staras K* Kemenes G* (2016) A two-neuron system for adaptive goal-directed decision-making. Nature Comms. doi: 10.1038/ncomms11793 *joint senior.

Rey SA, Smith CA, Fowler MW, Crawford F, Burden JJ, Staras K (2015) Ultrastructural and functional fate of recycled vesicles in hippocampal synapses. Nature Comms. doi: 10.1038/ncomms9043.

Marra V, Burden JJ, Thorpe J, Smith I, Smith SL, Hausser M, Branco T, Staras K (2012) A preferentially segregated recycling vesicle pool of limited size supports neurotransmission in native central synapses. Neuron. 76:579-589.

Ratnayaka A, Marra V, Branco T, Staras K (2011) Extrasynaptic vesicle recycling in mature hippocampal neurons. Nature Comms. 2:531 1-11.

Staras K, Branco T, Burden JJ, …, Darcy KJ, Marra V, Ratnayaka A, Goda Y (2010). A vesicle superpool spans multiple presynaptic terminals in hippocampal neurons. Neuron 66, 37-44.

Branco T, Staras K (2009) The probability of neurotransmitter release: variability and feedback control at single synapses. Nat. Rev. Neurosci. 10, 373-383.

Branco T, Staras K, Darcy KJ, Goda Y (2008) Local dendritic activity sets release probability at hippocampal synapses. Neuron. 59, 475-485.

Staras K (2007) Share and share alike: trading of presynaptic elements between central synapses. Trends Neurosci. 30, 292-298.

Darcy KJ, Staras K*, Collinson LM, Goda Y (2006) Constitutive sharing of recycling synaptic vesicles between presynaptic boutons. Nature Neurosci. 9, 315-321 *Joint first author.

long list

Biasetti L, Rey S, Fowler M, Ratnayaka A, Fennell K, Smith C, Marshall K, Hall C, Varga-Caballero M, Serpell L, Staras K. (2022) Elevated amyloid beta disrupts the nanoscale organization and function of synaptic vesicle pools in hippocampal neurons. Cereb Cortex (in press).

Rey S, Marra V, Smith C, Staras K. (2020) Nanoscale Remodeling of Functional Synaptic Vesicle Pools in Hebbian Plasticity. Cell Rep. 30:2006-2017. PUBMED link

Marshall KE, Vadukul DM, Staras K*, Serpell LC* (2020) Misfolded amyloid-β-42 impairs the endosomal-lysosomal pathway. Cell Mol Life Sci. PMID: 32025743 *joint senior and corresponding. PUBMED link

Roberts TP, Kern FB, Fernando C, Szathmáry E, Husbands P, Philippides AO, Staras K (2019) Encoding Temporal Regularities and Information Copying in Hippocampal Circuits. Sci Rep. 9:19036. PUBMED link

Crossley M, Staras K*, Kemenes G* (2018) A central control circuit for encoding perceived food value. Science Advances. 21 doi: 10.1126/sciadv.aau9180. *joint senior and corresponding. PUBMED link

Roshchin M, Matlashov ME, Ierusalimsky VN, Balaban PM, Belousov VV, Kemenes G*, Staras, K*, Nikitin, ES* (2018) A BK-channel-mediated feedback pathway links single-synapse activity with action potential sharpening in repetitive firing. Science Advances. 4(7):eaat1357 *joint senior and corresponding. PUBMED link

Hoch NC, Hanzlikova H, Rulten SL, Tétreault M, Komulainen E, Ju L, Hornyak P, Zeng Z, Gittens W, Rey SA, Staras K, Mancini GM, McKinnon PJ, Wang ZQ, Wagner JD; Care4Rare Canada Consortium, Yoon G, Caldecott KW (2017) XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia. Nature. doi: 10.1038/nature20790. PUBMED link

Shim Y, Philippides A, Staras K, Husbands P (2016) Unsupervised Learning in an Ensemble of Spiking Neural Networks Mediated by ITDP. PLoS Comput Biol. 12:e1005137. PUBMED link

Marshall KE, Vadukul DM, Dahal L, Theisen A, Fowler MW, Al-Hilaly Y, Ford L, Kemenes G, Day IJ, Staras K, Serpell LC (2016) A critical role for the self-assembly of Amyloid-β1-42 in neurodegeneration. Sci Rep. 2016 6:30182. PUBMED link

Crossley M, Staras K* Kemenes G* (2016) A two-neuron system for adaptive goal-directed decision-making. Nature Comms. doi: 10.1038/ncomms11793 *joint senior. PUBMED link

Rey SA, Smith CA, Fowler MW, Crawford F, Burden JJ, Staras K (2015) Ultrastructural and functional fate of recycled vesicles in hippocampal synapses. Nature Comms. doi: 10.1038/ncomms9043. PUBMED link

Fowler MW, Staras K (2015) Synaptic vesicle pools: principles, properties and limitations. Exp Cell Res. 335:150-156. PUBMED link

Marra V, Burden JJ, Crawford F, Staras K (2014) Ultrastructural readout of functional synaptic vesicle pools in hippocampal slice based on FM-dye-labeling and photoconversion. Nature Prot. 9:1337-1347. PUBMED link

Staras K, Mikulincer D, Gitler D (2013) Monitoring and quantifying dynamic physiological processes in live neurons using fluorescence recovery after photobleaching. J. Neurochem. 126:213-222.

Korneev SA, Kemenes I, Bettini NL, Kemenes G, Staras K, Benjamin PR, O’Shea M (2013) Axonal trafficking of an antisense RNA transcribed from a pseudogene is regulated by classical conditioning. Sci Rep. 2013;3:1027. doi: 10.1038/srep01027

Samu D, Marra V, Kemenes I, Crossley M, Kemenes G, Staras K, Nowotny T (2012) Single electrode dynamic clamp with StdpC. J Neurosci Methods. 211:11-21.

Ratnayaka A, Marra V, Bush D, Burden JJ, Branco T, Staras K (2012) Recruitment of resting vesicles into recycling pools supports NMDA-receptor dependent synaptic potentiation in cultured hippocampal neurons. J Physiol. 590:1585-1597. PUBMED link

Orenbuch A, Shalev L, Marra V, Sinai, I, Lavy Y, Kahn J, Burden J, Staras K, Gitler D (2012) Synapsin selectively controls the mobility of resting pool vesicles at hippocampal terminals. J Neurosci. 32:3969-3980. PUBMED link

Staras K, Branco T (2012) High-resolution approaches to studying presynaptic vesicle dynamics using variants of FRAP and electron microscopy. In: Cellular Imaging Techniques for Neuroscience and Beyond. Ed. Floris Wouterlood. Elsevier.

Soura V, Stewart Parker M, Willliams TL, Ratnayaka A, Atherton J, Gorringe K, Tuffin J, Darwent E, Rambaran R, Klein WL, Lacor PN, Staras K, Thorpe JR, Serpell LC (2012) Visualisation of colocalisation in Ab42-administered neuroblastoma cells reveals lysosome damage and autophagosome accumulation related to cell death. Biochem J. 441:579-590.

Ratnayaka A, Marra V, Branco T, Staras K (2011) Extrasynaptic vesicle recycling in mature hippocampal neurons. Nature Comms. 2:531 1-11. PUBMED link

Kemenes I, Marra V, Crossley M, Samu D, Staras K, Kemenes G, Nowotny T (2011) Dynamic Clamp with StdpC software. Nature Prot. 6, 405-417.

Staras K, Branco T (2010) Sharing vesicles between central presynaptic terminals: implications for synaptic function. Front Synapt Neurosci doi: 10.3389/fnsyn.2010.00020.

Staras K, Branco T, Burden JJ, Pozo K, Darcy KJ, Marra V, Ratnayaka A, Goda Y (2010). A vesicle superpool spans multiple presynaptic terminals in hippocampal neurons. Neuron 66, 37-44.

Branco T, Marra V, Staras K (2010) Examining size-strength relationships at hippocampal synapses using an ultrastructural measurement of synaptic release probability. J. Struct. Biol. 172: 203-210.

Benjamin PR, Staras K, Kemenes G (2010) What roles do tonic inhibition and disinhibition play in the control of motor programs? Front Behav Neurosci. 4, 30-37.

Branco T, Staras K (2009) The probability of neurotransmitter release: variability and feedback control at single synapses. Nat. Rev. Neurosci. 10, 373-383.

Branco T, Staras K, Darcy KJ, Goda Y (2008) Local dendritic activity sets release probability at hippocampal synapses. Neuron. 59, 475-485.

Staras K (2007) Share and share alike: trading of presynaptic elements between central synapses. Trends Neurosci. 30, 292-298.

Darcy KJ, Staras K*, Collinson LM, Goda Y (2006) An ultrastructural readout of fluorescence recovery after photobleaching using correlative light and electron microscopy. Nature Prot. 1, 988-994. *Joint first author.

Darcy KJ, Staras K*, Collinson LM, Goda Y (2006) Constitutive sharing of recycling synaptic vesicles between presynaptic boutons. Nature Neurosci. 9, 315-321 *Joint first author.

Kemenes I, Straub V, Staras K, O’Shea M, Kemenes G, Benjamin PR (2006) Role of delayed non-synaptic neuronal plasticity in long-term associative memory. Curr. Biol. 16, 1269-1279.

Nikitin E, Kiss T, Staras K, O’Shea M, Benjamin P, Kemenes G (2006) A persistent sodium current is a target for cAMP-induced neuronal plasticity in a state-setting modulatory interneuron. J. Neurophysiol. 95, 453-463.

Benjamin PR, Kemenes G, Staras K (2005) Molluscan Nervous Systems. In: Encyclopedia of Life Sciences. John Wiley & Sons Ltd: Chichester, [doi: 10.1038/npg.els.0004073].

Porta A, Montano N, Furlan R, Cogliati C, Guzzetti S, Gnecchi-Ruscone T, Malliani A, Chang HS, Staras K, Gilbey MP (2004) Automatic classification of interference patterns in driven event series: application to single sympathetic neuron discharge forced by mechanical ventilation. Biol. Cybern. 91, 258-273.

Staras K, Kemenes I, Benjamin PR, Kemenes G (2003) Loss of self-inhibition is a cellular mechanism for episodic rhythmic behavior. Curr. Biol. 13, 116-124.

Straub VA, Staras K, Kemenes G, Benjamin PR (2002) Endogenous and network properties of Lymnaea feeding central pattern generator interneurons. J. Neurophysiol. 88, 1569-1583.

Korneev SA, Kemenes I, Straub V, Staras K, Korneeva EI, Kemenes G, Benjamin PR, O’Shea M (2002) Suppression of nitric oxide (NO)-dependent behavior by double-stranded RNA-mediated silencing of a neuronal NO synthase gene. J. Neurosci. 22, RC227.

Staras K, Gyori J, Kemenes G (2002) Voltage-gated ionic currents in an identified modulatory cell type controlling molluscan feeding. Eur. J. Neurosci. 15, 109-119.

Staras K, Chang HS, Gilbey MP (2001) Reset of sympathetic rhythm by somatic afferents causes post-reflex coordination of sympathetic activity in rat. J. Physiol. 533, 537-545.

Kemenes G, Staras K, Benjamin PR (2001) Multiple types of control by identified interneurons in a sensory-activated rhythmic motor pattern. J. Neurosci. 21, 2903-2911.

Chang H-S, Staras K*, Gilbey MP (2000) Multiple oscillators provide metastability in rhythm generation. J. Neurosci.20:5135-5143 *Joint first author.

Benjamin PR, Staras K, Kemenes G (2000) A systems approach to the cellular analysis of associative learning in the pond snail Lymnaea. Learn. Mem. 7, 124-131.

Staras K, Kemenes G, Benjamin PR (1999) Cellular traces of behavioral conditioning can be recorded at several specific sites in a simple nervous system. J. Neurosci. 19, 347-357.

Chang H-S, Staras K, Smith JE, Gilbey MP (1999) Sympathetic neuronal oscillators are capable of dynamic synchronization.J. Neurosci. 19, 3183-3197.

Staras K, Kemenes G, Benjamin PR (1999) Electrophysiological and behavioral analysis of lip touch as a component of the food stimulus in unconditioned feeding of the snail Lymnaea. J. Neurophysiol. 81:1261-1273.

Staras K, Kemenes G, Benjamin PR (1998) Pattern-generating role for motoneurons in a rhythmically active neuronal network. J. Neurosci. 18, 3669-3688.

Staras K, Kemenes G, Benjamin PR (1998) Neurophysiological correlates of unconditioned and conditioned feeding behavior in the pond snail Lymnaea stagnalis. J. Neurophysiol. 79:3030-3040.

Kemenes G, Staras K, Benjamin PR (1997) In vitro classical conditioning of the feeding response in the pond snailLymnaea stagnalis. J. Neurophysiol. 78, 2351-2362.

Brierley MJ, Staras K, Benjamin PR (1997) Behavioural function of the putative glutamatergic interneuron, N2v, in the feeding system of the snail, Lymnaea: Plateauing properties and synaptic connections with retractor motor neurons. J. Neurophysiol. 78, 3386-3395.

Elphick MR, Kemenes G, Staras K, O’Shea M (1995) Behavioural role for nitric oxide in chemosensory activation of feeding in a mollusc. J. Neurosci. 15, 7653-7664.